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2007•Journal of Labelled Compounds and RadiopharmaceuticalsRequires access

Synthesis of the myoview™ ligand, [bisphosphinoethane‐1,2‐14C]tetrofosmin

Geoffrey T. Woolley, Sean L. Kitson, Robert G. B. Reid

Open publisher page 2 citations

Abstract

Abstract The carbon‐14 radiolabels in [bisphosphinoethane‐1,2‐14C]tetrofosmin ligand were readily introduced by reacting 1,2‐dibromo[U‐14C]ethane with bis(2‐ethoxyethyl)benzylphosphine (1). This was converted to the Myoview™ ligand in an overall yield of 45%. This radiosynthesis was important in obtaining marketing approval from the regulatory authorities and allowed Myoview™ to become one of the main heart imaging agents of today. Copyright © 2007 John Wiley & Sons, Ltd.

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What this paper is about

Abstract The carbon‐14 radiolabels in [bisphosphinoethane‐1,2‐14C]tetrofosmin ligand were readily introduced by reacting 1,2‐dibromo[U‐14C]ethane with bis(2‐ethoxyethyl)benzylphosphine (1). This was converted to the Myoview™ ligand in an overall yield of 45%. This radiosynthesis was important in obtaining marketing approval from the regulatory authorities and allowed Myoview™ to become one of the main heart imaging agents of today. Copyright © 2007 John Wiley & Sons, Ltd.

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Available abstract

Abstract The carbon‐14 radiolabels in [bisphosphinoethane‐1,2‐14C]tetrofosmin ligand were readily introduced by reacting 1,2‐dibromo[U‐14C]ethane with bis(2‐ethoxyethyl)benzylphosphine (1). This was converted to the Myoview™ ligand in an overall yield of 45%. This radiosynthesis was important in obtaining marketing approval from the regulatory authorities and allowed Myoview™ to become one of the main heart imaging agents of today. Copyright © 2007 John Wiley & Sons, Ltd.

Key concepts: Radiosynthesis, Chemistry, Ligand (biochemistry), Yield (engineering), Combinatorial chemistry, Radiochemistry, Nuclear medicine, Biochemistry

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