1973•Experimental Biology and MedicineRequires access

The Effect of Changes in Antral pH on the Basal Release of Gastrin

Heinz Becker, David D. Reeder, Jill C. Thompson

Abstract

Gastrin concentrations in the blood draining the gastric antrum were measured by radioimmunoassay during changes in the antral pH. Neutralization of the antrum (raising the basal ambient pH of 3.5-5 to 7 or 8) resulted in a significant increase of antral venous gastrin concentration. Acidification of the antrum significantly lowered, but did not abolish, the basal release of gastrin.

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Key concepts: Antrum, Gastrin, Basal (medicine), Radioimmunoassay, Internal medicine, Gastric antrum, Chemistry, Pyloric Antrum