2006•Annals of the New York Academy of SciencesRequires access

In Vitro TNF‐α and IL‐6 Production by Adherent Peripheral Blood Mononuclear Cells Obtained from Type 1 and Type 2 Diabetic Patients Evaluated according to the Metabolic Control

Maria Cristina Foss‐Freitas, Norma Tiraboschi Foss, Eduardo Antônio Donadi, Milton César Foss

Abstract

Tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) levels were evaluated in lipopolysaccharide (LPS)-stimulated cell cultured monocytes obtained from 24 type 1 and type 2 diabetic patients presenting inadequate (IN) or adequate (AD) metabolic control, and in 21 healthy individuals paired to patients for sex and age. The TNF-alpha levels in stimulated cultures of diabetic patients were similar to healthy individuals, and type 1 diabetic patients showed increased IL-6 supernatant levels. The tendency toward increased TNF-alpha and IL-6 levels was observed with metabolic control of type 1 and type 2 diabetic patients, suggesting that the control of diabetes improves the capacity of activation and maintenance of the proinflammatory immune response.

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Key concepts: Peripheral blood mononuclear cell, Tumor necrosis factor alpha, Proinflammatory cytokine, Endocrinology, Internal medicine, Metabolic control analysis, Lipopolysaccharide, Type 2 diabetes