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2009•Cancer Chemotherapy and PharmacologyOpen access

Co-administration of irinotecan decreases the plasma concentration of an active metabolite of amrubicin, amrubicinol in rats

Yukiko Maeda, Akinobu Hamada, Emiko Sanematsu, Ji-ichro Sasaki, Koji Yokoo, Asumi Hira, Hideyuki Saito

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Key concepts: Active metabolite, SN-38, Metabolite, Irinotecan, Pharmacokinetics, Chemistry, Glucuronide, Pharmacology

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Co-administration of irinotecan decreases the plasma concentration of an active metabolite of amrubicin, amrubicinol in rats — Research Paper | ScholarLens