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1962•The Journal of Experimental MedicineOpen access

THE ROLE OF INTERFERON IN VACCINIA VIRUS INFECTION OF MOUSE EMBRYO TISSUE CULTURE

Lowell A. Glasgow, Karl Habel

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Abstract

The production of an interferon-like substance by vaccinia virus is described. The physical properties of vaccinia interferon are shown to be similar to those of previously reported interferons. Data defining the role of vaccinia interferon in cell resistance and in establishment and maintenance of a carrier culture are presented. Elimination of virus from an infected culture is demonstrated and the role of interferon in the recovery process is considered.

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What this paper is about

The production of an interferon-like substance by vaccinia virus is described. The physical properties of vaccinia interferon are shown to be similar to those of previously reported interferons. Data defining the role of vaccinia interferon in cell resistance and in establishment and maintenance of a carrier culture are presented. Elimination of virus from an infected culture is demonstrated and the role of interferon in the recovery process is considered.

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Available abstract

The production of an interferon-like substance by vaccinia virus is described. The physical properties of vaccinia interferon are shown to be similar to those of previously reported interferons. Data defining the role of vaccinia interferon in cell resistance and in establishment and maintenance of a carrier culture are presented. Elimination of virus from an infected culture is demonstrated and the role of interferon in the recovery process is considered.

Key concepts: Vaccinia, Interferon, Virology, Virus, Embryo, Biology, Tissue culture, Viral Interference

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