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2013•Angewandte Chemie International EditionOpen access

Synthesis of Stable Peptide Nucleic Acid‐Modified Gold Nanoparticles and their Assembly onto Gold Surfaces

Philipp Anstaett, Yuanhui Zheng, Thibaut Thai, Alison M. Funston, Udo Bach, Gilles Gasser

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Abstract

PNA does it better: Peptide nucleic acid (PNA) oligomers were attached to gold nanoparticles (AuNPs) through a variety of mono- and trithiol linkers. These functionalized particles had sufficient stability for sequence-specific self-assembly onto gold surfaces (see figure) in the absence of ions or surfactants. The nanoparticle surface densities obtained were superior to comparable DNA-modified AuNPs.

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What this paper is about

PNA does it better: Peptide nucleic acid (PNA) oligomers were attached to gold nanoparticles (AuNPs) through a variety of mono- and trithiol linkers. These functionalized particles had sufficient stability for sequence-specific self-assembly onto gold surfaces (see figure) in the absence of ions or surfactants. The nanoparticle surface densities obtained were superior to comparable DNA-modified AuNPs.

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Available abstract

PNA does it better: Peptide nucleic acid (PNA) oligomers were attached to gold nanoparticles (AuNPs) through a variety of mono- and trithiol linkers. These functionalized particles had sufficient stability for sequence-specific self-assembly onto gold surfaces (see figure) in the absence of ions or surfactants. The nanoparticle surface densities obtained were superior to comparable DNA-modified AuNPs.

Key concepts: Colloidal gold, Peptide nucleic acid, Nucleic acid, Peptide, Nanoparticle, Nanotechnology, Combinatorial chemistry, Chemistry

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