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2005•Annals of the New York Academy of SciencesRequires access

Expression of Proopiomelanocortin and Its Cleavage Enzyme Genes in Rana esculenta and Xenopus laevis Gonads

Marcello Carotti, Massimo Nabissi, Gilberto Mosconi, Fran�oise Gangnon, Isabelle Lihrmann, Hubert Vaudry, Alberta Maria Polzonetti-Magni

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Abstract

Proopiomelanocortin (POMC) is the precursor protein of different hormones and neuropeptides, and the POMC-derived peptides are produced through proteolytic cleavage. Prohormone convertase PC1 and PC2 are enzymes responsible for the cleavage of the POMC prohormone. The coexpression of POMC, PC1, and PC2 genes was previously described in the brain and the pituitary gland of Rana esculenta and Xenopus laevis, but no data are available for the gonad. The present work demonstrates a gonadal POMC convertase gene expression in Rana esculenta and Xenopus laevis.

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What this paper is about

Proopiomelanocortin (POMC) is the precursor protein of different hormones and neuropeptides, and the POMC-derived peptides are produced through proteolytic cleavage. Prohormone convertase PC1 and PC2 are enzymes responsible for the cleavage of the POMC prohormone. The coexpression of POMC, PC1, and PC2 genes was previously described in the brain and the pituitary gland of Rana esculenta and Xenopus laevis, but no data are available for the gonad. The present work demonstrates a gonadal POMC convertase gene expression in Rana esculenta and Xenopus laevis.

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Available abstract

Proopiomelanocortin (POMC) is the precursor protein of different hormones and neuropeptides, and the POMC-derived peptides are produced through proteolytic cleavage. Prohormone convertase PC1 and PC2 are enzymes responsible for the cleavage of the POMC prohormone. The coexpression of POMC, PC1, and PC2 genes was previously described in the brain and the pituitary gland of Rana esculenta and Xenopus laevis, but no data are available for the gonad. The present work demonstrates a gonadal POMC convertase gene expression in Rana esculenta and Xenopus laevis.

Key concepts: Xenopus, Proopiomelanocortin, Prohormone, Prohormone convertase, Biology, Cleavage (geology), Gene, Salientia

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Expression of Proopiomelanocortin and Its Cleavage Enzyme Genes in Rana esculenta and Xenopus laevis Gonads — Research Paper | ScholarLens