2007•Neurobiology of DiseaseOpen access

An inverse agonist of the histamine H3 receptor improves wakefulness in narcolepsy: Studies in orexin−/− mice and patients

Jian‐Sheng Lin, Yves Dauvilliers, Isabelle Arnulf, Hélène Bastuji, Christelle Anaclet, Régis Parmentier, Laurence Kocher, Masashi Yanagisawa, Philippe Lehert, Xavier Ligneau, David Perrin, Philippe Robert, Michel Roux, Jeanne-Marie Lecomte, J. Schwartz

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Key concepts: Narcolepsy, Wakefulness, Modafinil, Cataplexy, Orexin, Excessive daytime sleepiness, Inverse agonist, Agonist