2009•Antimicrobial Agents and ChemotherapyOpen access
Molecular Mechanisms of Macrolide Resistance in Clinical Isolates of Mycoplasma pneumoniae from China
Deli Xin, MI Zu-huang, Xu Han, Ling Qin, Jing Li, Tianli Wei, Xiaogeng Chen, Shaojie Ma, Ancun Hou, Li Gui, Dawei Shi
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Abstract
Fifty clinical Mycoplasma pneumoniae strains were isolated from 370 children with respiratory tract infections. Four strains were susceptible to macrolides, while the other 46 (92%) were macrolide resistant. The molecular mechanism of resistance was shown to be associated with point mutations in 23S rRNA at positions 2063 and 2064.