1980•British Journal of PharmacologyOpen access

METERGOLINE AND CYPROHEPTADINE SUPPRESS PROLACTIN RELEASE BY A NON‐5‐HYDROXYTRYPTAMINERGIC, NON‐DOPAMINERGIC MECHANISM

G. M. Besser, Giuseppe Delitala, Ashley Grossman, Tun Kuan Yeo

Abstract

A dispersed rat anterior pituitary cell system has been used to investigate the effects of cyproheptadine and metergoline on prolactin secretion. Both drugs were potent inhibitors of prolactin secretion. However, the inhibition was not antagonized by either 5-hydroxytryptamine or a variety of dopamine antagonists. We conclude that both drugs act through mechanisms that are neither 5-hydroxytryptaminergic nor dopaminergic.

Open-access reader

About this research paper

What this paper is about

Why it matters

OpenAlex reports 16 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Metergoline, Cyproheptadine, Dopaminergic, Prolactin, Dopamine, Endocrinology, Secretion, Internal medicine