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COMPARISON BETWEEN THE SCINTIGRAPHIC UPTAKE AND PLASMA CLEARANCE OF99 m Tc‐DIETHYLENETRIAMINEPENTACETIC ACID (DTPA) FOR THE EVALUATION OF THE GLOMERULAR FILTRATION RATE IN DOGS

Paul Y. Barthez, William J. Hornof, Larry D. Cowgill, Larry A. Neal, Paul Mickel

Open publisher page 55 citations

Abstract

The scintigraphically measured percentage dose uptake of 99mTc-DTPA by the kidneys and the plasma clearance of 99mTc-DTPA have been reported to correlate well with inulin clearance. These two parameters were evaluated in seven dogs with known or suspected naturally occurring renal disease and compared to simultaneously measured renal inulin clearance. Correlation between inulin clearance and the 99mTc-DTPA plasma clearance was better (p = .0016) than the correlation between the percentage DTPA uptake by the kidney. It was concluded that measurement of 99mTc-DTPA plasma clearance is a more accurate method to estimate global glomerular filtration rate (GFR) than the percentage kidney uptake.

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What this paper is about

The scintigraphically measured percentage dose uptake of 99mTc-DTPA by the kidneys and the plasma clearance of 99mTc-DTPA have been reported to correlate well with inulin clearance. These two parameters were evaluated in seven dogs with known or suspected naturally occurring renal disease and compared to simultaneously measured renal inulin clearance. Correlation between inulin clearance and the 99mTc-DTPA plasma clearance was better (p = .0016) than the correlation between the percentage DTPA uptake by the kidney. It was concluded that measurement of 99mTc-DTPA plasma clearance is a more accurate method to estimate global glomerular filtration rate (GFR) than the percentage kidney uptake.

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OpenAlex reports 55 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

The scintigraphically measured percentage dose uptake of 99mTc-DTPA by the kidneys and the plasma clearance of 99mTc-DTPA have been reported to correlate well with inulin clearance. These two parameters were evaluated in seven dogs with known or suspected naturally occurring renal disease and compared to simultaneously measured renal inulin clearance. Correlation between inulin clearance and the 99mTc-DTPA plasma clearance was better (p = .0016) than the correlation between the percentage DTPA uptake by the kidney. It was concluded that measurement of 99mTc-DTPA plasma clearance is a more accurate method to estimate global glomerular filtration rate (GFR) than the percentage kidney uptake.

Key concepts: Renal function, Inulin, Plasma clearance, Clearance rate, Medicine, Clearance, Kidney, PAH clearance

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COMPARISON BETWEEN THE SCINTIGRAPHIC UPTAKE AND PLASMA CLEARANCE OF99 m Tc‐DIETHYLENETRIAMINEPENTACETIC ACID (DTPA) FOR THE EVALUATION OF THE GLOMERULAR FILTRATION RATE IN DOGS — Research Paper | ScholarLens