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2009•International Archives of Allergy and Applied ImmunologyRequires access

Differential Effect of Vinblastine and Colchicine on Human Active and Total T Rosettes

Joseph Wybran, André Govaerts, H. Hugh Fudenberg

Open publisher page 5 citations

Abstract

The effect of vinblastine and colchicine on human blood T cell rosette formation with sheep erythrocytes was assessed. For some concentrations, both drugs increased the percentage of active T rosettes. In contrast, the total T rosette percentage was decreased by the same drugs. These experiments further confirm the heterogeneity of T cell rosettes and suggest the existence of three types of sheep red blood cell receptors on human blood T lymphocytes.

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What this paper is about

The effect of vinblastine and colchicine on human blood T cell rosette formation with sheep erythrocytes was assessed. For some concentrations, both drugs increased the percentage of active T rosettes. In contrast, the total T rosette percentage was decreased by the same drugs. These experiments further confirm the heterogeneity of T cell rosettes and suggest the existence of three types of sheep red blood cell receptors on human blood T lymphocytes.

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OpenAlex reports 5 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

The effect of vinblastine and colchicine on human blood T cell rosette formation with sheep erythrocytes was assessed. For some concentrations, both drugs increased the percentage of active T rosettes. In contrast, the total T rosette percentage was decreased by the same drugs. These experiments further confirm the heterogeneity of T cell rosettes and suggest the existence of three types of sheep red blood cell receptors on human blood T lymphocytes.

Key concepts: Vinblastine, Colchicine, Rosette formation, Rosette (schizont appearance), Receptor, Biology, Immunology, Blood cell

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