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1983•Hoppe-Seyler´s Zeitschrift für physiologische ChemieRequires access

Immuno-Cross-Reactivity between α-Macroglobulins from Pig, Dog, Rat and Man Including Human Pregnancy-Associated α2-Glycoprotein

Björn Weström, Börje W. Karlsson, Kjell OHLSSON

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Abstract

The antigenic relationships between the alpha-macroglobulins in human blood plasma and in serum from pig, dog and rat were investigated using ordinary immunoelectrophoresis and line immunoelectrophoresis. The results imply that these alpha-macroglobulins are more or less antigenically related. This is true also for human pregnancy-associated alpha 2-glycoprotein which is the only alpha-macroglobulin without reported proteinase-inhibiting properties. Among the alpha-macroglobulins a reciprocal cross-reactivity was observed for eight pairs, indicating a close structural relationship.

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What this paper is about

The antigenic relationships between the alpha-macroglobulins in human blood plasma and in serum from pig, dog and rat were investigated using ordinary immunoelectrophoresis and line immunoelectrophoresis. The results imply that these alpha-macroglobulins are more or less antigenically related. This is true also for human pregnancy-associated alpha 2-glycoprotein which is the only alpha-macroglobulin without reported proteinase-inhibiting properties. Among the alpha-macroglobulins a reciprocal cross-reactivity was observed for eight pairs, indicating a close structural relationship.

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Available abstract

The antigenic relationships between the alpha-macroglobulins in human blood plasma and in serum from pig, dog and rat were investigated using ordinary immunoelectrophoresis and line immunoelectrophoresis. The results imply that these alpha-macroglobulins are more or less antigenically related. This is true also for human pregnancy-associated alpha 2-glycoprotein which is the only alpha-macroglobulin without reported proteinase-inhibiting properties. Among the alpha-macroglobulins a reciprocal cross-reactivity was observed for eight pairs, indicating a close structural relationship.

Key concepts: Immunoelectrophoresis, Glycoprotein, Alpha (finance), Pregnancy, Immunology, Molecular biology, Antibody, Chemistry

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Immuno-Cross-Reactivity between α-Macroglobulins from Pig, Dog, Rat and Man Including Human Pregnancy-Associated α2-Glycoprotein — Research Paper | ScholarLens