1983•FEBS LettersRequires access

Cytosol Mg2+ modulates Ca2+ ionophore induced secretion from rabbit neutrophils

Francesco Di Virgilio, Bastien D. Gomperts

Abstract

The influence of extracellular Mg2+ on Ca2+ ionophore (A23187 and ionomycin) induced secretion and changes in the cytosol pH of rabbit neutrophils suspended in Ca2+-free buffer has been investigated. While extracellular Ca2+ is obligatory for ionomycin induced secretion, we have defined conditions under which A23187 can induce secretion in Ca2+-free media. The different behaviour of these two Ca2+ ionophores is discussed on the basis of their different counter cation specificities.

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Key concepts: Ionophore, Cytosol, Secretion, Chemistry, Calcium, Biophysics, Rabbit (cipher), Isotopes of calcium