2011•British Journal of NeurosurgeryRequires access
Two cases of unexpected long-term improvement of Parkinson's disease after subthalamic nucleus deep brain stimulation removal
Sui H. Wong, Paul Eldridge, Andrew J. Duffy, Susan H. Fox, T.R.K. Varma, Nicholas Fletcher
Open publisher page 2 citations
Abstract
S. H. Wong*a, P. R. Eldridgeb, A. Duffya, S. H. Fox*c, T. R. K. Varmab & N. A. Fletcheraa Departments of Neurology1b Neurosurgery2, The Walton Centre, Liverpool, UKc Movement Disorders Clinic, University of Toronto, Toronto Western Hospital, Ontario, CanadaCorrespondence: Sui H. Wong, Department of Neurology, The Walton Centre NHS Foundation Trust, Lower Lane, Liverpool L9 7LJ, UK. Tel: +44 151 529 5701. Fax: +44 151 529 5512. E-mail: suiwong@doctors.org.uk*Previously at The Walton Centre, Liverpool.†RetiredTwo patients with Parkinson's disease (PD) treated successfully with subthalamic nucleus deep brain stimulation (STN-DBS) for 3–4 years are reported, who demonstrated a persistent improvement following removal of STN-DBS for late infection. Possible hypotheses are discussed – whether a microlesioning effect or a disease-modifying effect of STN-DBS, though neither adequately explain this phenomenon.