2006•Mini-Reviews in Medicinal ChemistryRequires access

Currently Available Drugs for the Treatment of Obesity: Sibutramine and Orlistat

Jean‐Philippe Chaput, Sylvie St‐Pierre, André Ulmann Dominique Tremblay

Abstract

The currently available drugs for long-term treatment of obesity are sibutramine and orlistat. They have been shown to be able to induce significant weight loss, with important co-morbidity reduction, allowing the maintenance of reduced body weight for at least 1-2 years. Cardiostimulating and gastrointestinal adverse effects are however not negligible. Keywords: Pharmacotherapy, sibutramine, orlistat, body weight, fat, energy balance, physical activity, diet

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Key concepts: Sibutramine, Orlistat, Weight loss, Medicine, Obesity, Adverse effect, Management of obesity, Pharmacotherapy