1994•Analytical ProceedingsRequires access

Atmospheric pressure ionization liquid chromatography–mass spectrometry in the quantification of drugs in biological fluids

J N Robson, Sally Draper, Karen Tennant

Abstract

The application of atmospheric pressure ionization liquid chromatography–mass spectrometry to the analysis of drugs is described. The techniques are electrospray and atmospheric pressure chemical ionization. Examples are shown of quantitative analysis with electrospray operating in the ng ml–1 range and atmospheric pressure chemical ionization in the pg ml–1 range.

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Available abstract

Key concepts: Atmospheric-pressure chemical ionization, Mass spectrometry, Direct electron ionization liquid chromatography–mass spectrometry interface, Chromatography, Electrospray ionization, Desorption electrospray ionization, Atmospheric pressure, Chemistry