2016•Journal of Pharmacological and Toxicological MethodsRequires access

New in vitro model for proarrhythmia safety screening: IKs inhibition potentiates the QTc prolonging effect of IKr inhibitors in isolated guinea pig hearts

Péter Kui, Szabolcs Orosz, Hedvig Takács, Annamária Sarusi, Norbert Csík, Ferenc Rárosi, Csongor Csekõ, András Varró, Julius Gy. Papp, Tamás Forster, Attila S. Farkas, András Farkas, András Farkas, András Farkas

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Key concepts: Proarrhythmia, QT interval, Dofetilide, Cisapride, Torsades de pointes, Pharmacology, hERG, Sotalol