1981•Journal of Pharmacy and PharmacologyRequires access

The acetylenic monoamine oxidase inhibitors clorgyline, deprenyl, pargyline and J-508: their properties and applications

Christopher John Fowler, Lars Oreland, Brian A. Callingham

Abstract

Abstract The article presents a short review of some of the properties of the acetylenic inhibitors of monoamine oxidase currently under investigation: clorgyline, (—)-deprenyl, pargyline and J-508. Their substrate-selective inactivation, mechanism of inhibition, titration and pharmacology with respect to monoamine oxidase are critically discussed.

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Available abstract

Key concepts: Clorgyline, Pargyline, Monoamine oxidase, Chemistry, Pharmacology, Iproniazid, Monoamine neurotransmitter, Monoamine oxidase inhibitor