2008•Organic & Biomolecular ChemistryRequires access
A direct and stereospecific approach to the synthesis of α-glycosyl thiols
Ravindra T. Dere, Yingxi Wang, Xiangming Zhu
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Abstract
A new simple method for the synthesis of alpha-glycosyl thiols is described. Ring-opening of 1,6-anhydrosugars with commercially available bis(trimethylsilyl)sulfide under the action of catalytic amounts of TMSOTf smoothly afforded alpha-glycosyl thiols in very high yields and in a stereospecific way.