Indocyanine Green-Plasma Half Time Clearance (T 1/2) in Normal Beagles.
Walter J. Krasavage, Sol M. Michaelson
Abstract
Walter J. Krasavage, Sol M. Michaelson
Abstract
1. The mean plasma clearance half time of indocyanine green (ICG) was found to be 5.6 ± 0,8§ minutes in male beagles, and 7.0 ± 1.48 in female beagles, 2. Female dogs in this study cleared ICG significantly more slowly than the males. 3. Plasma volume estimated using ICG is 3 7.7 ± 6.0 ml/kg. This figure agrees with 37.5 ± 6.1 ml/kg found using radioiron (Fe-59).
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1. The mean plasma clearance half time of indocyanine green (ICG) was found to be 5.6 ± 0,8§ minutes in male beagles, and 7.0 ± 1.48 in female beagles, 2. Female dogs in this study cleared ICG significantly more slowly than the males. 3. Plasma volume estimated using ICG is 3 7.7 ± 6.0 ml/kg. This figure agrees with 37.5 ± 6.1 ml/kg found using radioiron (Fe-59).
Key concepts: Indocyanine green, Clearance, Plasma clearance, Plasma volume, Chemistry, Metabolic clearance rate, Plasma levels, Nuclear medicine