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2000•Nucleosides Nucleotides & Nucleic AcidsRequires access

Replacement of the Phosphodiester Bond Between U4 and G5 in the U-Turn of a Chemically Modified Hammerhead Ribozyme by an Amide Bond

Martin Dunkel, Vivian Reither

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Abstract

The phosphodiester bond between U4 and G5 in the U-turn of a chemically modified hammerhead ribozyme was substituted by an amide backbone without compromising the ribozyme's cleavage activity. Furthermore, the modified ribozyme proved to be completely stable against endonucleolytic digestion at this position.

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What this paper is about

The phosphodiester bond between U4 and G5 in the U-turn of a chemically modified hammerhead ribozyme was substituted by an amide backbone without compromising the ribozyme's cleavage activity. Furthermore, the modified ribozyme proved to be completely stable against endonucleolytic digestion at this position.

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Available abstract

The phosphodiester bond between U4 and G5 in the U-turn of a chemically modified hammerhead ribozyme was substituted by an amide backbone without compromising the ribozyme's cleavage activity. Furthermore, the modified ribozyme proved to be completely stable against endonucleolytic digestion at this position.

Key concepts: Phosphodiester bond, Hammerhead ribozyme, Ribozyme, Chemistry, Peptide bond, VS ribozyme, Hairpin ribozyme, Amide

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Replacement of the Phosphodiester Bond Between U4 and G5 in the U-Turn of a Chemically Modified Hammerhead Ribozyme by an Amide Bond — Research Paper | ScholarLens