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NEWER PHENOTHIAZINE DRUGS IN TREATMENT OF NERVOUS DISORDERS

John Kinross-Wright

Open publisher page 49 citations

Abstract

The two most recent tranquilizing derivatives of phenothiazine are trifluoperazine (Stelazine) and thioridazine (Mellaril). The former is the most potent phenothiazine compound available. Its side-effects, predominantly extrapyramidal in nature, may be adequately controlled in the hospital, but the drug is not recommended for office patients unless given in very small doses. Thioridazine has about one-tenth the potency, weight for weight, of trifluoperazine but, in equivalent doses, is free of significant side-effects, including Parkinsonism. It is recommended for use in both the hospital and office.

About this research paper

What this paper is about

The two most recent tranquilizing derivatives of phenothiazine are trifluoperazine (Stelazine) and thioridazine (Mellaril). The former is the most potent phenothiazine compound available. Its side-effects, predominantly extrapyramidal in nature, may be adequately controlled in the hospital, but the drug is not recommended for office patients unless given in very small doses. Thioridazine has about one-tenth the potency, weight for weight, of trifluoperazine but, in equivalent doses, is free of significant side-effects, including Parkinsonism. It is recommended for use in both the hospital and office.

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OpenAlex reports 49 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

The two most recent tranquilizing derivatives of phenothiazine are trifluoperazine (Stelazine) and thioridazine (Mellaril). The former is the most potent phenothiazine compound available. Its side-effects, predominantly extrapyramidal in nature, may be adequately controlled in the hospital, but the drug is not recommended for office patients unless given in very small doses. Thioridazine has about one-tenth the potency, weight for weight, of trifluoperazine but, in equivalent doses, is free of significant side-effects, including Parkinsonism. It is recommended for use in both the hospital and office.

Key concepts: Phenothiazine, Thioridazine, Trifluoperazine, Parkinsonism, Medicine, Potency, Perphenazine, Pharmacology

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