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2006•Diabetes Obesity and MetabolismRequires access

Raised alanine transaminase and decreased adiponectin are features of the metabolic syndrome in patients with type 2 diabetes

Ingrid J. Hickman, Jonathan P. Whitehead, Johannes B. Prins, Graeme A. Macdonald

Open publisher page 12 citations

Abstract

AIM: The aim of the study was to investigate the relationship between the metabolic syndrome (MS), adiponectin and abnormal liver enzymes in patients with type 2 diabetes. METHODS: Fasting serum was collected from 189 patients with type 2 diabetes, adiponectin was measure using radioimmunoassay and features of the MS were assessed. RESULTS: Mean ALT was significantly higher in patients with the MS and higher ALT was associated with lower adiponectin levels. As the number of features of MS increased, ALT increased and adiponectin decreased independent of glycaemic control. CONCLUSION: Hypoadiponectinemia and the MS may be linked with liver injury in patients with type 2 diabetes.

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What this paper is about

AIM: The aim of the study was to investigate the relationship between the metabolic syndrome (MS), adiponectin and abnormal liver enzymes in patients with type 2 diabetes. METHODS: Fasting serum was collected from 189 patients with type 2 diabetes, adiponectin was measure using radioimmunoassay and features of the MS were assessed. RESULTS: Mean ALT was significantly higher in patients with the MS and higher ALT was associated with lower adiponectin levels. As the number of features of MS increased, ALT increased and adiponectin decreased independent of glycaemic control. CONCLUSION: Hypoadiponectinemia and the MS may be linked with liver injury in patients with type 2 diabetes.

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OpenAlex reports 12 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

AIM: The aim of the study was to investigate the relationship between the metabolic syndrome (MS), adiponectin and abnormal liver enzymes in patients with type 2 diabetes. METHODS: Fasting serum was collected from 189 patients with type 2 diabetes, adiponectin was measure using radioimmunoassay and features of the MS were assessed. RESULTS: Mean ALT was significantly higher in patients with the MS and higher ALT was associated with lower adiponectin levels. As the number of features of MS increased, ALT increased and adiponectin decreased independent of glycaemic control. CONCLUSION: Hypoadiponectinemia and the MS may be linked with liver injury in patients with type 2 diabetes.

Key concepts: Adiponectin, Internal medicine, Alanine transaminase, Type 2 diabetes, Endocrinology, Medicine, Metabolic syndrome, Aspartate transaminase

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