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1989•The Japanese Journal of PharmacologyOpen access

Effects of mepacrine on the oxidation of (1-14C)oleate in isolated rat hepatocytes.

Masaru Chihara, Takahide Nomura, Masakatsu Tachibana, Hiroko Nomura, Yukihiko Nomura, Yasumichi Hagino

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Abstract

In isolated rat hepatocytes, mepacrine stimulated the conversion of [1-14C]oleate into 14CO2 and depressed the formation of acid-soluble products from [1-14C]oleate. The action of mepacrine on [1-14C]oleate oxidation was not affected by exogenously applied phospholipase A2 (from Crotalus adamanteus venom) or arachidonic acid. It is suggested that mepacrine may exert its metabolic effects in isolated rat hepatocytes by a mechanism independent of phospholipase A2 inhibition.

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In isolated rat hepatocytes, mepacrine stimulated the conversion of [1-14C]oleate into 14CO2 and depressed the formation of acid-soluble products from [1-14C]oleate. The action of mepacrine on [1-14C]oleate oxidation was not affected by exogenously applied phospholipase A2 (from Crotalus adamanteus venom) or arachidonic acid. It is suggested that mepacrine may exert its metabolic effects in isolated rat hepatocytes by a mechanism independent of phospholipase A2 inhibition.

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Available abstract

In isolated rat hepatocytes, mepacrine stimulated the conversion of [1-14C]oleate into 14CO2 and depressed the formation of acid-soluble products from [1-14C]oleate. The action of mepacrine on [1-14C]oleate oxidation was not affected by exogenously applied phospholipase A2 (from Crotalus adamanteus venom) or arachidonic acid. It is suggested that mepacrine may exert its metabolic effects in isolated rat hepatocytes by a mechanism independent of phospholipase A2 inhibition.

Key concepts: Mepacrine, Arachidonic acid, Phospholipase A2, Phospholipase, Phospholipase A, Chemistry, Biochemistry, Biology

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Effects of mepacrine on the oxidation of (1-14C)oleate in isolated rat hepatocytes. — Research Paper | ScholarLens