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SERUM LIDOCAINE LEVELS FOLLOWING SPINAL ANESTHESIA WITH LIDOCAINE AND LIDOCAINE AND EPINEPHRINE IN DOGS

R Ravindran, Oscar J. Viegas, Karen L. Pantazis, S. J. Baldwin

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Abstract

Arterial lidocaine concentrations and the duration of motor anesthesia following the subarachnoid injection of 30 or 40 mg of lidocaine with or without epinephrine 0.3 mg were measured in 10 sedated dogs. As the dogs were sedated with ketamine, the duration of sensory anesthesia was not evaluated. Each dog served as its own control with alternating treatments at a 7-day interval. The maximum arterial lidocaine concentration occurred 15 minutes after subarachnoid injection and was not different (p > 0.05) with lidocaine (820 ng/ml) or lidocaine-epinephrine (990 ng/ml). However, the mean duration of motor anesthesia was prolonged 46 percent ( p

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What this paper is about

Arterial lidocaine concentrations and the duration of motor anesthesia following the subarachnoid injection of 30 or 40 mg of lidocaine with or without epinephrine 0.3 mg were measured in 10 sedated dogs. As the dogs were sedated with ketamine, the duration of sensory anesthesia was not evaluated. Each dog served as its own control with alternating treatments at a 7-day interval. The maximum arterial lidocaine concentration occurred 15 minutes after subarachnoid injection and was not different (p > 0.05) with lidocaine (820 ng/ml) or lidocaine-epinephrine (990 ng/ml). However, the mean duration of motor anesthesia was prolonged 46 percent ( p

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Available abstract

Arterial lidocaine concentrations and the duration of motor anesthesia following the subarachnoid injection of 30 or 40 mg of lidocaine with or without epinephrine 0.3 mg were measured in 10 sedated dogs. As the dogs were sedated with ketamine, the duration of sensory anesthesia was not evaluated. Each dog served as its own control with alternating treatments at a 7-day interval. The maximum arterial lidocaine concentration occurred 15 minutes after subarachnoid injection and was not different (p > 0.05) with lidocaine (820 ng/ml) or lidocaine-epinephrine (990 ng/ml). However, the mean duration of motor anesthesia was prolonged 46 percent ( p

Key concepts: Lidocaine, Medicine, Anesthesia, Epinephrine, Ketamine, Subarachnoid space, Cerebrospinal fluid, Internal medicine

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SERUM LIDOCAINE LEVELS FOLLOWING SPINAL ANESTHESIA WITH LIDOCAINE AND LIDOCAINE AND EPINEPHRINE IN DOGS — Research Paper | ScholarLens