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2004•Journal of General VirologyRequires access

Unusually long target site duplications flanking some of the long terminal repeats of human endogenous retrovirus K in the human genome

Ilgar Z. Mamedov, Yuri B. Lebedev, E. D. Sverdlov

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Abstract

Human endogenous retroviruses (HERVs) make up a substantial part of the human genome. HERVs and solitary long terminal repeats (solo LTRs) are usually flanked by 4-6 nt short direct repeats through the well-known mechanism of their integration. A number of solo LTRs flanked by unusually long direct repeats were detected in the human genome. These unusual structures might be a product of an alternative virus insertion mechanism.

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What this paper is about

Human endogenous retroviruses (HERVs) make up a substantial part of the human genome. HERVs and solitary long terminal repeats (solo LTRs) are usually flanked by 4-6 nt short direct repeats through the well-known mechanism of their integration. A number of solo LTRs flanked by unusually long direct repeats were detected in the human genome. These unusual structures might be a product of an alternative virus insertion mechanism.

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OpenAlex reports 7 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Human endogenous retroviruses (HERVs) make up a substantial part of the human genome. HERVs and solitary long terminal repeats (solo LTRs) are usually flanked by 4-6 nt short direct repeats through the well-known mechanism of their integration. A number of solo LTRs flanked by unusually long direct repeats were detected in the human genome. These unusual structures might be a product of an alternative virus insertion mechanism.

Key concepts: Long terminal repeat, Biology, Direct repeat, Endogenous retrovirus, Genome, Genetics, Human genome, Retrovirus

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Unusually long target site duplications flanking some of the long terminal repeats of human endogenous retrovirus K in the human genome — Research Paper | ScholarLens