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2011•ASME 2011 Summer Bioengineering Conference, Parts A and BRequires access

Computational Model of Thrombosis: A Study of Transport as a Determinant of Rapid Platelet Accumulation

David Bark, David N. Ku

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Abstract

Thrombus is commonly found in the plaque region of atherosclerosis, leading to acute myocardial infarction, known as a heart attack. Arterial thrombosis, which is mostly composed of platelets, can occlude a blood vessel by accumulating enough platelets to block blood flow. Understanding the relative contribution of platelet transport and platelet adhesion to thrombus growth rates is germane to predicting and treating at-risk lesions for thrombus growth.

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What this paper is about

Thrombus is commonly found in the plaque region of atherosclerosis, leading to acute myocardial infarction, known as a heart attack. Arterial thrombosis, which is mostly composed of platelets, can occlude a blood vessel by accumulating enough platelets to block blood flow. Understanding the relative contribution of platelet transport and platelet adhesion to thrombus growth rates is germane to predicting and treating at-risk lesions for thrombus growth.

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Available abstract

Thrombus is commonly found in the plaque region of atherosclerosis, leading to acute myocardial infarction, known as a heart attack. Arterial thrombosis, which is mostly composed of platelets, can occlude a blood vessel by accumulating enough platelets to block blood flow. Understanding the relative contribution of platelet transport and platelet adhesion to thrombus growth rates is germane to predicting and treating at-risk lesions for thrombus growth.

Key concepts: Thrombus, Platelet, Thrombosis, Cardiology, Myocardial infarction, Medicine, Platelet adhesion, Internal medicine

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