Human Skin Grafted Upon the Chorioallantois of the Chick Embryo for Virus Cultivation

(1) Human skin may readily be grafted onto the chorioallantoic membrane of embryonated eggs. (2) The prepuce removed by usual surgical circumcision is a satisfactory source of adequate amounts of skin. (3) Penicillin and streptomycin obviate most bacterial contamination. (4) Grafted human skin may be passed serially from egg to egg at weekly intervals and remain viable. (5) Herpes simplex and vaccinia grow readily on grafted human skin, with the formation of characteristic inclusion bodies. (6) A successful inoculation with herpes zoster confirms the previous single successful cultivation of this virus outside of the human body.