1987•Antimicrobial Agents and ChemotherapyOpen access

Absence of ototoxicity of teichomycin A2 in guinea pigs

Robert E. Brummett, K. E. Fox, Mark E. Warchol, D. L. Himes

Abstract

Teichomycin A2 is a new antibiotic that is similar to vancomycin. Because vancomycin is reported to be ototoxic, teichomycin A2 was tested for ototoxicity. No evidence of ototoxicity was found. Furthermore, ethacrynic acid, a diuretic that augments the ototoxicity of many drugs, did not enhance ototoxicity with teichomycin A2.

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Available abstract

Key concepts: Ototoxicity, Vancomycin, Antibiotics, Guinea pig, Medicine, Diuretic, Antibacterial agent, Pharmacology