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NON-LACTOGENIC EFFECTS OF GROWTH HORMONE ON GROWTH AND INSULIN-LIKE GROWTH FACTOR-I MESSENGER RIBONUCLEIC ACID OF RAT MAMMARY GLAND

David L. Kleinberg, Weifeng Ruan, Veronica M. Catanese, Connie B. Newman, Mark L. Feldman

Open publisher page 107 citations

Abstract

In contrast to established dogma that PRL is central in mammary development, and GH mimics PRL in affecting growth because of structural similarities, we found that both hGH, which is lactogenic, and rGH, which is non-lactogenic, were significantly more potent than hPRL and rPRL in stimulating mammary growth in rats. Additionally, hGH was more potent than hPRL in increasing mammary IGF-I mRNA content. These data indicate that GH has separate effects on parameters of mammary gland growth, suggesting an independent role for GH in mammary growth.

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What this paper is about

In contrast to established dogma that PRL is central in mammary development, and GH mimics PRL in affecting growth because of structural similarities, we found that both hGH, which is lactogenic, and rGH, which is non-lactogenic, were significantly more potent than hPRL and rPRL in stimulating mammary growth in rats. Additionally, hGH was more potent than hPRL in increasing mammary IGF-I mRNA content. These data indicate that GH has separate effects on parameters of mammary gland growth, suggesting an independent role for GH in mammary growth.

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OpenAlex reports 107 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

In contrast to established dogma that PRL is central in mammary development, and GH mimics PRL in affecting growth because of structural similarities, we found that both hGH, which is lactogenic, and rGH, which is non-lactogenic, were significantly more potent than hPRL and rPRL in stimulating mammary growth in rats. Additionally, hGH was more potent than hPRL in increasing mammary IGF-I mRNA content. These data indicate that GH has separate effects on parameters of mammary gland growth, suggesting an independent role for GH in mammary growth.

Key concepts: Endocrinology, Internal medicine, Prolactin, Mammary gland, Biology, Somatomedin, Growth factor, Growth hormone

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