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1996•Journal of Veterinary Medical ScienceOpen access

Persistence of High Virus Neutralizing Antibody Titers in Cats Experimentally Infected with Feline Immunodeficiency Virus.

Yasuo Inoshima, Yasuhiro Ikeda, Mariko Kohmoto, Marcelo Ricardo Ítalo Pecoraro, Masayuki Shimojima, Yukako SHIMOJIMA, Gouki Inada, Yasushi Kawaguchi, Keizō Tomonaga, Takayuki Miyazawa, T. Mikami

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Abstract

The development of virus neutralizing (VN) antibody is one of the most effective host defense mechanisms against virus infection. In the present study, we developed a new VN assay against feline immunodeficiency virus (FIV) using a feline T-lymphoblastoid cell line, MYA-1 cells, based on inhibition of viral reverse transcriptase production. This assay is applicable to strains of FIV which can not infect CRFK cells. By using the assay, we examined long-term responses of VN antibody in cats experimentally infected with FIV. VN antibody titers increased progressively during first 30 weeks post inoculation and remained at high titers thereafter for 7 years of observation periods.

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What this paper is about

The development of virus neutralizing (VN) antibody is one of the most effective host defense mechanisms against virus infection. In the present study, we developed a new VN assay against feline immunodeficiency virus (FIV) using a feline T-lymphoblastoid cell line, MYA-1 cells, based on inhibition of viral reverse transcriptase production. This assay is applicable to strains of FIV which can not infect CRFK cells. By using the assay, we examined long-term responses of VN antibody in cats experimentally infected with FIV. VN antibody titers increased progressively during first 30 weeks post inoculation and remained at high titers thereafter for 7 years of observation periods.

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Available abstract

The development of virus neutralizing (VN) antibody is one of the most effective host defense mechanisms against virus infection. In the present study, we developed a new VN assay against feline immunodeficiency virus (FIV) using a feline T-lymphoblastoid cell line, MYA-1 cells, based on inhibition of viral reverse transcriptase production. This assay is applicable to strains of FIV which can not infect CRFK cells. By using the assay, we examined long-term responses of VN antibody in cats experimentally infected with FIV. VN antibody titers increased progressively during first 30 weeks post inoculation and remained at high titers thereafter for 7 years of observation periods.

Key concepts: Virology, Feline immunodeficiency virus, Virus, Titer, Antibody, Neutralizing antibody, CATS, Biology

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Persistence of High Virus Neutralizing Antibody Titers in Cats Experimentally Infected with Feline Immunodeficiency Virus. — Research Paper | ScholarLens