1994•Magnetic Resonance in MedicineOpen access

Magnetization transfer affects the proton creatine/phosphocreatine signal intensity: In vivo demonstration in the rat brain

Wolfgang Dreher, David Gordon Norris, Dieter Leibfritz

Abstract

The effect of off-resonance preirradiation on proton spectra acquired from the healthy rat brain at 4.7 T is examined using a PRESS sequence. The creatine/phosphocreatine (Cr/PCr) signal at 3.0 ppm decreases in signal intensity for offset frequencies between +/- 10 kHz. This cannot be explained by RF bleedover, but is attributed to magnetization transfer between two pools of Cr/PCr, one with a long T2 relaxation time giving the observed NMR signal, the other corresponding to a broad resonance line being completely or partially saturated by off-resonance preirradiation. Possible interpretations of these results are discussed.

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Key concepts: Phosphocreatine, Magnetization transfer, Nuclear magnetic resonance, Creatine, Proton, Relaxation (psychology), Chemistry, Nuclear magnetic resonance spectroscopy