2001•International Journal of Molecular MedicineRequires access
Expression of the α1D subunit of the L-type voltage gated calcium channel in human liver
Toshihiro Okamoto, Seong-Yong Jeong, Yūji Takahashi, Kenneth Lee Baughman, Katsuhisa Ogata, Jun Goto, Ichiro Kanazawa
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Abstract
Calcium channel blocker is useful for a variety of purposes and is effective for preventing hepatitis elicited by different inducers, suggesting its possible clinical application for treating hepatitis. The alpha1-subunit of the dihydropyridine-sensitive L-type calcium channel is a target of calcium channel blocker. For clinical application of calcium channel blocker, it is important to analyze the expression of the L-type calcium channel in the liver. However, the subtype of the L-type calcium channel alpha1-subunit expressed in the liver was not known. In the present study, the alpha1-subunit of the calcium channel expressed in human liver was systematically analyzed. The alpha1D subunit of the dihydropyridine-sensitive L-type voltage gated calcium channel is expressed relatively strongly in the liver and may play an important role in the liver.