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Regulation of signal transduction by -adrenergic hormone receptors

Ernst Helmreich, Thomas Pfeuffer

Abstract

Research on structure and function of ~-adrenergic receptors and its interactions with guanyl nucleotide binding proteins which activate or inhibit adenylate cyclase has progressed to the molecular level. The purification of all components of the signal transfer chain from ~-receptor to adenylate cyclase now allows the interaction of pure components to be studied in 'reconstituted' lipid vesicles.

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Available abstract

Key concepts: Adenylate kinase, Cyclase, Receptor, Growth-hormone-releasing hormone receptor, Signal transduction, G protein-coupled receptor, Cell biology, Chemistry