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2003•Chemistry LettersRequires access

An Amino Acid Co-catalyzed Asymmetric Aldol Reaction

Ming Gao, Jian Gao, Benjamin S. Lane, Ralph A. Zingaro

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Abstract

Abstract A series of chiral amino acids were found to be effective catalysts in an asymmetric aldol reaction between 4-nitrobenzaldehyde and acetone. Lewis acids and bases were found to effectively promote this reaction. Enantioselectivities greater than 74% (ee) and product yields over 85% were achieved under optimum conditions.

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Abstract A series of chiral amino acids were found to be effective catalysts in an asymmetric aldol reaction between 4-nitrobenzaldehyde and acetone. Lewis acids and bases were found to effectively promote this reaction. Enantioselectivities greater than 74% (ee) and product yields over 85% were achieved under optimum conditions.

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Available abstract

Abstract A series of chiral amino acids were found to be effective catalysts in an asymmetric aldol reaction between 4-nitrobenzaldehyde and acetone. Lewis acids and bases were found to effectively promote this reaction. Enantioselectivities greater than 74% (ee) and product yields over 85% were achieved under optimum conditions.

Key concepts: Chemistry, Aldol reaction, Catalysis, Lewis acids and bases, Acetone, Lewis acid catalysis, Enantioselective synthesis, Organic chemistry

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