UO‐Catalyzed Oligothioadenylate Synthesis with High Regio‐ and Stereoselectivity

Products with 2′-5′-linkages and Rp configurations result from the stereoselective UO-catalyzed oligomerization of the adenosine derivative 1, although the starting monomer was used as a mixture of diastereomers. The high regio-and stereoselectivity observed here is rarely encountered except in enzymatic reactions.