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Different effects of chlorpromazine on bleomycin-and epirubicin induced cytotoxicity

Kjell Grankvist, Per Bergström, Roger Henriksson

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Abstract

The effect of the antiemetic chlorpromazine on bleomycin- and epirubicin cytotoxicity was tested in vitro. Chlorpromazine (0.1 or 0.01 mg/l) enhanced epirubicin-induced toxicity to cultured Chinese fibroblasts whereas 0.01 mg/l chlorpromazine inhibited the cytotoxicity of bleomycin. The results encourage further studies on the effects of commonly used antiemetics on the cytotoxicity and antitumoral effects of anticancer chemotherapeutics.

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What this paper is about

The effect of the antiemetic chlorpromazine on bleomycin- and epirubicin cytotoxicity was tested in vitro. Chlorpromazine (0.1 or 0.01 mg/l) enhanced epirubicin-induced toxicity to cultured Chinese fibroblasts whereas 0.01 mg/l chlorpromazine inhibited the cytotoxicity of bleomycin. The results encourage further studies on the effects of commonly used antiemetics on the cytotoxicity and antitumoral effects of anticancer chemotherapeutics.

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OpenAlex reports 2 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

The effect of the antiemetic chlorpromazine on bleomycin- and epirubicin cytotoxicity was tested in vitro. Chlorpromazine (0.1 or 0.01 mg/l) enhanced epirubicin-induced toxicity to cultured Chinese fibroblasts whereas 0.01 mg/l chlorpromazine inhibited the cytotoxicity of bleomycin. The results encourage further studies on the effects of commonly used antiemetics on the cytotoxicity and antitumoral effects of anticancer chemotherapeutics.

Key concepts: Cytotoxicity, Chlorpromazine, Epirubicin, Bleomycin, Pharmacology, Chemistry, In vitro, Toxicity

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