Sexual dysfunction among male patients on antidepressant theraphy

Introduction Sexual dysfunction is common among individuals with major depressive disorder but not optimally treated often. Objectives The aim of this study was to determine differece in sexual dysfunction among male patients on antidepressant theraphy. Methods Stadu group consisted of 69 male outpatients who met DSM IV criteria for Major depressive disorder; aged 21–65 (mean 46.3 years). Studu excluded patients: with a previous history of sexual dysfunction, somatic diseases, other psychiatric co morbid condition. They did not used medication able to cause sexual dysfunction unless antidepressants or medications to improve erectile dysfunction. The ASEX and HDRS scales were applied at a single interview. Results The prevalence of sexual dysfunction observed was 66% patients, 57, 7% in group under 50 and 74, 3% in group being 50 years old or older. Sexual dysfunction, revealed by a high score on the ASEX scale (mean overall score of 26.9) was in group of patient over 50 years old. (p < 0, 01). There are no statistical, significant differences in the points obtained on the HDRS scores in both groups. (p < 0.01). Sexual dysfunction were reported more frequently in patients taking TCA (p < 0.005) or SSRIs (p < 0.001) compared to patients treated with mirtazapine. The use of TCA is associated with loss of libido and erectile dysfunction, SSRIs with delayed ejaculation as well as impairment of libido and arousal. Conclusions Frequency of sexual dysfunction is higher in patients over 50 years. The less impact on sexual function have mirtazapine.