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Effect of X-irradiation on vitamin B12 binding capacity to intrinsic factor.

Dorin Dsouza, U. K. Vakil, A. Sreenivasan

Abstract

The effects of whole-body X-irradiation on vitamin B12-protein complex formation in gastric juice after oral administration of [57Co]-B12 have been studied. Two proteins with B12-binding activity have been isolated by gel filtration from gastric juice. 57Co-activity, recovered from B12-protein complex in gastric juice, is found to be about 30% less in the X-irradiated rat. In serum, vitamin B12 is mainly associated with alpha1-globulin. Radioactivity distribution in serum globulins after intraperitoneal injection of [57Co]-B12 was similar in control and X-irradiated rats.

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Key concepts: Vitamin B12, Intrinsic factor, Chemistry, Irradiation, Vitamin, Size-exclusion chromatography, Internal medicine, Endocrinology