2004•Organic LettersRequires access
Effect on p K a of Metal-Bound Water Molecules in Lanthanide Ion-Induced Cyclen “Cavities”
Thorfinnur Gunnlaugsson, Dermot F. Brougham, Ann-Marie Fanning, M. Nieuwenhuyzen, John E. O’Brien, Romain Viguier
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Abstract
[reaction: see text] The macrocyclic cyclen conjugates 1-4 were synthesized with the aim of forming lanthanide ion-based macrocyclic conjugates possessing deep cavities, formed upon complexation to various lanthanide ions. These complexes all possess metal-bound water molecules, where the pKa of the water molecules depends on the nature of the cavity.