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SUPPRESSION OF PROLACTIN AND THYROTROPIN SECRETION IN THE RAT BY ANTISERUM TO THYROTROPIN-RELEASING HORMONE

Yitzhak Koch, G. Goldhaber, I. Fireman, Uriel Zor, Jashovam Shani, Eli Tal

Open publisher page 68 citations

Abstract

Administration of antiserum to synthetic thyrotropin-releasing hormone (TRH) to male and female rats cause a 50% and a 70% suppression in serum levels of prolactin and thyrotropin, respectively, as compared with controls injected with normal rabbit serum. The degree of suppression was similar in diestrous and proestrous female rats and in male rats. These findings support the view that, in addition to its original designation, TRH also has a physiological role in regulating release of pituitary prolactin.

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What this paper is about

Administration of antiserum to synthetic thyrotropin-releasing hormone (TRH) to male and female rats cause a 50% and a 70% suppression in serum levels of prolactin and thyrotropin, respectively, as compared with controls injected with normal rabbit serum. The degree of suppression was similar in diestrous and proestrous female rats and in male rats. These findings support the view that, in addition to its original designation, TRH also has a physiological role in regulating release of pituitary prolactin.

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OpenAlex reports 68 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Administration of antiserum to synthetic thyrotropin-releasing hormone (TRH) to male and female rats cause a 50% and a 70% suppression in serum levels of prolactin and thyrotropin, respectively, as compared with controls injected with normal rabbit serum. The degree of suppression was similar in diestrous and proestrous female rats and in male rats. These findings support the view that, in addition to its original designation, TRH also has a physiological role in regulating release of pituitary prolactin.

Key concepts: Internal medicine, Endocrinology, Thyrotropin-releasing hormone, Prolactin, Antiserum, Secretion, Hormone, Pituitary gland

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SUPPRESSION OF PROLACTIN AND THYROTROPIN SECRETION IN THE RAT BY ANTISERUM TO THYROTROPIN-RELEASING HORMONE — Research Paper | ScholarLens