1967•Experimental Biology and MedicineRequires access

Replication of Rubella Virus in a Continuous Line of African Green Monkey Kidney Cells (Vero).

Harvey Liebhaber, James T. Riordan, Dirk Horstmann

Abstract

Rubella virus has been found to grow to high titer in a continuous line of green monkey kidney cells (Vero), with the production of CPE and plaques. Infectivity titrations can be read within 2 weeks and are somewhat higher than comparable titers measured by echovirus 11 interference in pGMK. Primary isolation rates of 56% were obtained in Vero cultures as compared to 12% with the same specimens tested in pGMK cultures. Complement fixing antigen can be produced in satisfactory titer in Vero cultures, and the system is suitable for the direct measurement of neutralizing antibody.

About this research paper

What this paper is about

Why it matters

OpenAlex reports 28 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Vero cell, African Green Monkey, Virology, Titer, Biology, Infectivity, Neutralizing antibody, Rubella