Comparison of Tolbutamide and Insulin Pre-Treatment Prior to Alloxan Induced Diabetes

1) Starvation or glucose plus tolbutamide potentiates the diabetogenic activity of alloxan with increased mortality. 2) Glucose alone or glucose plus insulin protects against alloxan diabetes. 3) Different results obtained with insulin or tolbutamide cannot be explained on the basis of liver glycogen content, blood glucose, or theoretical status of pancreatic activity at time of alloxan injection.