2015•New Journal of ChemistryRequires access

Regioselective nucleophilic aromatic substitution reactions of 5,7-dinitroquinazoline-4-one and 5,7-dinitroquinazoline-4-thione with methylamine: a mechanistic consideration

Amritpal Singh, Neetu Goel

Abstract

Thiocarbonyls, similar to carbonyls, are able to provide regioselective control for the attack of amines at the peri -position of 5,7-dinitroquinazoline-4-thione through intramolecular N–H–SC hydrogen bonding.

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Key concepts: Chemistry, Regioselectivity, Intramolecular force, Methylamine, Electrophilic aromatic substitution, Nucleophilic substitution, Substitution reaction, Medicinal chemistry