Comparison of miconazole– and ketoconazole–induced release of K+ from Candida species

Relatively high concentrations of miconazole caused immediate and rapid release of K+ from strains of Candida albicans and Can. parapsilosis. Ketoconazole did not. These results support the recent hypothesis that ketonocazole, unlike related antifungal imidazole-containing drugs, cannot exert a direct membrane damaging effect.