1978•Cell Biology International ReportsRequires access
Stimulation of cell proliferation by histamine H receptors in dimethylhydrazine-induced adenocarcinomata
Peter J. M. Tutton, David H. Barkla
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Abstract
Cell proliferation in dimethylhydrazine-induced colonic carcinomata was stimulated by histamine and by the histamine H2 receptor agonist dimaprit and inhibited by the histamine H2 receptor antagonists Metiamide and Cimetidine but not by the histamine H1 receptor antagonist Mepyramine. In contrast histamine had no effect on colonic crypt cell proliferation in normal or dimethylhydrazine-treated rats.