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1990•Isotopenpraxis Isotopes in Environmental and Health StudiesRequires access

A Rapid Aqueous Phase Preparation Procedure for 131I-Labelled Meta-Iodobenzylguanidine (MIBG)

G. Wollny, U. Welzel

Open publisher page 4 citations

Abstract

The process for catalytic radioiodine labelling of m-iodobenzyglunidine is described. This labelling procedure will be used in the routine-production process. A radiochemical yield below 80% is obtained at 100°C within 15 min. Separating unbonded iodine −131I the radiochemical purity is more than 98‰. After labelling the solution is made isotonic and brought on a pH of 5.5–6.5. By sterile filtration an injectable solution is obtained.

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What this paper is about

The process for catalytic radioiodine labelling of m-iodobenzyglunidine is described. This labelling procedure will be used in the routine-production process. A radiochemical yield below 80% is obtained at 100°C within 15 min. Separating unbonded iodine −131I the radiochemical purity is more than 98‰. After labelling the solution is made isotonic and brought on a pH of 5.5–6.5. By sterile filtration an injectable solution is obtained.

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Available abstract

The process for catalytic radioiodine labelling of m-iodobenzyglunidine is described. This labelling procedure will be used in the routine-production process. A radiochemical yield below 80% is obtained at 100°C within 15 min. Separating unbonded iodine −131I the radiochemical purity is more than 98‰. After labelling the solution is made isotonic and brought on a pH of 5.5–6.5. By sterile filtration an injectable solution is obtained.

Key concepts: Labelling, Radiochemistry, Chemistry, Yield (engineering), Iodine, Filtration (mathematics), Aqueous solution, Chromatography

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A Rapid Aqueous Phase Preparation Procedure for 131I-Labelled Meta-Iodobenzylguanidine (MIBG) — Research Paper | ScholarLens