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1959•New England Journal of MedicineRequires access

The Effect of Penicillin on Acute Rheumatic Fever and Valvular Heart Disease

Edward A. Mortimer, Vaisman B. Samuel, Vignau I. Alberto, Guasch L. Julio, Schuster C. Augusto, Louis Rakita, Richard M. Krause, Richard B. Roberts, Charles H. Rammelkamp

Open publisher page 42 citations

Abstract

THE control of symptoms of acute rheumatic fever is easily attained by several methods of therapy, but no form of treatment has had a marked effect on acute carditis and valvular heart disease, the two complications that determine the ultimate prognosis. Since the initiating event of the acute rheumatic episode is infection by the Group A streptococcus, it appeared logical to attempt to alter the course of established rheumatic fever by removing the original inciting agent. To accomplish this objective, 49 patients with acute rheumatic fever received large doses of penicillin, and 48 patients received no antibiotic and served as . . .

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What this paper is about

THE control of symptoms of acute rheumatic fever is easily attained by several methods of therapy, but no form of treatment has had a marked effect on acute carditis and valvular heart disease, the two complications that determine the ultimate prognosis. Since the initiating event of the acute rheumatic episode is infection by the Group A streptococcus, it appeared logical to attempt to alter the course of established rheumatic fever by removing the original inciting agent. To accomplish this objective, 49 patients with acute rheumatic fever received large doses of penicillin, and 48 patients received no antibiotic and served as . . .

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OpenAlex reports 42 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

THE control of symptoms of acute rheumatic fever is easily attained by several methods of therapy, but no form of treatment has had a marked effect on acute carditis and valvular heart disease, the two complications that determine the ultimate prognosis. Since the initiating event of the acute rheumatic episode is infection by the Group A streptococcus, it appeared logical to attempt to alter the course of established rheumatic fever by removing the original inciting agent. To accomplish this objective, 49 patients with acute rheumatic fever received large doses of penicillin, and 48 patients received no antibiotic and served as . . .

Key concepts: Medicine, Acute rheumatic fever, Carditis, Rheumatic fever, Penicillin, Antibiotics, valvular heart disease, Heart disease

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