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Endogenous Cholecystokinin Reduces Feeding in Young Rats

Aron Weller, Gerard P. Smith, James Gibbs

Abstract

The hypothesis that endogenous cholecystokinin (CCK) released from the small intestine during feeding causes satiety was tested in rat pups, 9 to 12 days old. Intragastric administration of soybean trypsin inhibitor, a procedure that releases CCK from the small intestine, decreased the subsequent intake of a test meal. This effect was reversed by prior treatment with MK-329, a selective antagonist of CCK at alimentary-type CCK (CCK-A) receptors. Thus, endogenous, small intestinal CCK can cause satiety in the neonatal rat and this effect involves CCK-A receptors.

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Key concepts: Cholecystokinin, Endogeny, Cholecystokinin receptor, Internal medicine, Endocrinology, Antagonist, Small intestine, Receptor